The research group works in the fields off: vascular effects of flavonoids and other compounds of natural origin. valorization of food extracts and waste from agricultural production. cardiovascular toxic effects of new anticancer and multidrug resistance reverting agents. new modulators of vascular ion channels
We are a synthetic organic group specializing in making molecules with stimuli responsive properties. We assemble molecules to make nanocontainers that are responsive to stimuli such as light, pH and chemical stimuli for applications in drug delivery.
Research activities are: study of the physiological mechanisms of intra- and extra-cellular antioxidant defense and evaluation of the main biomarkers of oxidative stress. nitric oxide (NO), nitrosothiols and other NOx: study of their function and metabolism. study of the antioxidant properties of some new chemical entities. study of the effect of the intra- and extracellular redox balance modulation on the progression of some pathological states.
The research group works in: Development and use of pharmacological and biochemical in vitro models (primary cells, cell cultures, isolated tissues/organs) for: 1.Pharmacology/safety pharmacology/cardiovascular toxicology of newly synthesized compounds, extracts, or purified compounds of natural origin. 2.Recycling and valorization of agricultural and food by-products: evaluation of protective properties against cardiovascular diseases.
The research group focuses on the study of molecular interactions in complex systems and matrices through the combined use of various analysis techniques, including nuclear magnetic resonance ( spectroscopy, capable of monitoring all components present in a sample in a single experiment.
The research group works in the following fields: development of epigenetic and non-epigenetic modulators for the treatment of hematologic tumors. design and synthesis of inhibitors targeting enzymes of the endocannabinoid system for the development of therapeutic agents for neurodegenerative diseases and epilepsy treatment. synthesis of new pharmacological tools for the treatment of rare diseases. Design and synthesis of enzymatic inhibitors or receptor modulators for the development of new infectious agents. Green chemistry methods for the development of new neurodegeneration modulators.
The research group is concerned with the study of the molecular mechanisms of angiogenesis (in neovascular retinopathies and tumors ) and tumor development . Within the group there is also an active line of translational research aimed at the development of bioactive molecules with anti angiogenesis and anti tumor functions.
The research activity mainly concerns with the development of new materials for environmental and biomedical applications, through: chemical and electrochemical deposition of surface layers of organic, inorganic and hybrid materials. the study by voltammetric techniques of inorganic/organometallic complexes and molecules. characterization of composition and structure of solid surfaces and nanoparticles. spectroscopic characterization
Computer simulation of spectroscopy and chemical and photochemical reactivity at the molecular level. Computer simulation of the activation of biological photoreceptors and fluorescent proteins.
The research activities of the group are focused on the development, preparation, and characterization of intelligent nanomaterials, particularly: development of polysaccharide and lipid-based nanocarriers. development of tissue substitutes. drafting of analysis protocols. conformational and dynamic analysis of biomolecules