Therapeutics for Covid-19 patients
The invention concerns the use of DNA aptamers that can shield the SARS-CoV-2 binding site on the cell, and halt the cell-to-cell spreading of coronavirus.
Composition of an hydro-alcoholic solution of grape pomace extract, and application thereof for reducing the exogenus oxidative stress in dermal cell
The invention relates to an hydro-alcoholic solution extract of selected grape pomace, a cosmetic formulation comprising such hydro-alcoholic solution extract, the method for incorporating the hydro-alcoholic solution extract into a cosmetic formulation and the final use of the as-obtained cosmetic formulation.
New Dendrimeric Pyrrolidines
The invention proposes a new approach to rare genetic diseases for which no cures are available, only symptomatic treatments through the preparation of novel multivalent molecules active toward the human enzymes responsible for them
Antagonism of B3 adrenoceptor for the treatment of cancer immune tolerance
The invention relates to the use of beta-blocking compounds, in particular the antagonist of ?3 adrenoceptor (?3-ARs), for the treatment of immune-tolerance associated with pathological states, such as cancer.
A_Atrofi: New compounds for the treatment of musculoskeletal atrophy and cachexia
The invention is represented by a mixture of molecules, called A_ATROFI, capable of regulating the balance between protein synthesis and its degradation in skeletal muscle cells.
New activators of SIRT1 enzyme for the treatment of cardiovascular and cardiometabolic pathologies
The present invention targets a class of compounds able to activate the enzyme SIRT1 in humans by regulating numerous metabolic functions. The appropriately designed compounds could be used in pharmaceutical formulations, preferably in the treatment or prevention of cardiometabolic diseases
New molecules for bone tissue regeneration
The present invention concerns the development of new pharmacologically active compounds for the treatment of osteoporosis and in general bone diseases characterized by progressive loss of bone mass, such as rheumatoid arthritis, hyperparathyroidism, and bone cancer metastases.
1,3-DIAZO-4-OXA-[3.3.1]- bicyclic derivatives, process for their manufacture and their use as a medicament in particular for treating diabetes
The present invention concerns the synthesis of small molecules, obtained by a totally innovative process, characterized by a stimulatory effect on the secretion of GLP-1, a gastrointestinal hormone.
Monoacylglycerol lipase (MAGL) inhibitors
The new patented compounds are based on a potent reversible noncovalent mechanism of action, which is useful for treating MAGL-mediated diseases, such as neuroinflammation/degeneration, pain, multiple sclerosis/amyotrophic lateral sclerosis, Alzheimer's disease, and Parkinson's disease.
Highly selective inhibitors of adams activity
The invention concerns the development of appropriately designed and synthesized chemical entities that selectively exert their activity on ADAMs, A Disintegrin And Metalloproteinase (ADAM) enzyme.