Broad spectrum antivirals The group identified active compounds against emerging viruses (i e Zika, Dengue, SARS COV 2). Analysis of novel foods and circular economy Study the upcycling by products in insects Analysis of the influence insect derived components in the prevention of cardiovascular diseases
The research group works in: Development and use of pharmacological and biochemical in vitro models (primary cells, cell cultures, isolated tissues/organs) for: 1.Pharmacology/safety pharmacology/cardiovascular toxicology of newly synthesized compounds, extracts, or purified compounds of natural origin. 2.Recycling and valorization of agricultural and food by-products: evaluation of protective properties against cardiovascular diseases.
Our research activity adopts a ONE HEALTH approach while applying post genomics (proteomics, metabolomics), cell biology, biochemistry, computational biochemistry and AI in Life Sciences, sustainable pharmaceuticals and circular bioeconomy.
The research group works in the following fields: development of epigenetic and non-epigenetic modulators for the treatment of hematologic tumors. design and synthesis of inhibitors targeting enzymes of the endocannabinoid system for the development of therapeutic agents for neurodegenerative diseases and epilepsy treatment. synthesis of new pharmacological tools for the treatment of rare diseases. Design and synthesis of enzymatic inhibitors or receptor modulators for the development of new infectious agents. Green chemistry methods for the development of new neurodegeneration modulators.
The research group is concerned with the study of the molecular mechanisms of angiogenesis (in neovascular retinopathies and tumors ) and tumor development . Within the group there is also an active line of translational research aimed at the development of bioactive molecules with anti angiogenesis and anti tumor functions.
The research activities of the BioStructLab are focus on gene manipulation by recombinant DNA technique, production of biological macromolecules ( RNA and DNA), and structural characterization by structural biology techniques The
The research group is focused on two key areas, synthetic organic chemistry and computational chemistry, which are highly complementary and in complete synergy with each other. the research group is interested in the development of new chemical methodologies in the medicinal chemistry context and in the study of the interaction between the drug and its macromolecular target
The patent application protects nontoxic small molecules (glycomimetics), easily obtained from natural compounds (carbohydrates), which can be used for personalized treatment of glycan-related diseases
The research activity consists in high resolution transcriptomics to identify cancer specific subpopulations and interactions with cancer cells and the Tumor Microenvironment (TME), also adopting spatial transcriptomics and proteomics
The invention refers to the use of an engineered 'Clustered Regularly Interspersed Short Palindromic Repeat (CRISPR)-CRISPR associated (Cas)’ (CRISPR-Cas) technology targeting a sequence mutated at one or more loci in the genome of a given eukaryotic cell
